Presenter Bailey Francis
Authors Bailey A. Francis1†, Latasha Ludwig2,3†, Chang He4,5†, Melanie Dobromylskyj6, Christof A. Bertram7, Heike Aupperle-Lellbach8,9, Hannah Wong10, Aiden P. Foster11, Mark J. Arends12, Alejandro Suárez-Bonnet13, Simon L. Priestnall13, Laetitia Tatiersky14, Fernanda Castillo-Alcala15, Angie Rupp16, Arlene Khachadoorian2, Eda Parlak7, Marine Inglebert4,5, Shevaniee Umamaheswaran1, Saamin Cheema1, Martin Del Castillo Velasco-Herrera1, Kim Wong1, Ian C. Vermes1, Jamie Billington1, Sven Rottenberg4,17, Geoffrey A. Wood2, David J. Adams1, Louise van der Weyden1
Affiliations †These authors contributed equally to this work. 1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, Cambridgeshire, CB10 1SA, U.K. 2Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2W1, Canada. 3Department of Population Medicine and Diagnostic Sciences, Cornell University, College of Veterinary Medicine, Ithaca, NY, 14853, USA. 4Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland. 5Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland. 6Finn Pathologists, One-Eyed Lane, Weybread, Diss, Norfolk, IP21 5TT, UK. 7Institute of Pathology, University of Veterinary Medicine Vienna, Wien, Austria. 8Laboklin GmbH & Co. KG, Laboratory for Clinical Diagnostics, 97688 Bad Kissingen, Germany. 9Institute of Pathology, School of Medicine, Technical University of Munich, Trogerstrasse 18, 81675 Munich, Germany. 10Department of Veterinary Medicine, University of Cambridge, Cambridge, Cambridgeshire, CB3 0ES, UK. 11Bristol Veterinary School, University of Bristol, Langford House, Langford, North Somerset, BS40 5DU, UK. 12University of Edinburgh, Edinburgh Pathology, Centre for Comparative Pathology, CRUK Scotland Centre, Institute of Genetics and Cancer, Crewe Road South, Edinburgh, EH4 2XR, Scotland. 13Department of Pathobiology and Population Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA, UK. 14VETPATH Canada, Guelph, Ontario, NIG 2W1, Canada. 15Tāwharau Ora-School of Veterinary Science, Massey University, Palmerston North 4474, New Zealand. 16School of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, G61 1QH, Scotland. 17Bern Center for Precision Medicine and Cancer Therapy Resistance Cluster, Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland.
Presentation Type Talk
Abstract
Cancer is a common cause of morbidity and mortality in domestic cats. Since the mutational landscape of feline tumours remains largely uncharacterised, we performed sequencing of 493 feline tumor-normal tissue pairs from 13 tumor types, focusing on the feline orthologs of ~1,000 human cancer genes. The most frequently mutated gene was TP53, and the most recurrent copy number alterations were loss of PTEN or FAS, or gain of MYC. Through the identification of driver genes, mutational signatures, viral sequences, and tumor-predisposing germline variants, our study provides the first insight into the domestic cat oncogenome. We demonstrate key similarities with the human oncogenome, confirming the cat as a valuable model for comparative studies, and using a ‘One Medicine’ approach we identify potentially actionable mutations.