Presenter pawprints
Authors Oliver Forman1, Abigail Kerr2, Jamie Freyer1, Jason Huff1, Luke Bawazer1, Michelle Daya1, Rebecca Chodroff Foran1
Affiliations 1. Wisdom Panel, Mars Science and Diagnostics, Fountain Valley, CA, US 2.Veterinary Specialists Scotland, Linnaeus Veterinary Limited, Mars Veterinary Health, Livingston, United Kingdom
Presentation Type Talk
Abstract
Canine atopic dermatitis (CAD) is a common inflammatory skin condition in dogs. It is a lifelong issue that poses a significant welfare concern due to the chronic skin discomfort and pruritus (itching) experienced by affected animals. Access to a large population of dogs genotyped on a medium-density single-nucleotide polymorphism array through commercial Wisdom Panel testing, along with their linked clinical records, allows large-scale, highly powered genome-wide association studies (GWAS) to be performed. In a large CAD GWAS using over 28,000 dogs, a signal on canine chromosome 38 was identified, with subsequent whole-genome resequencing revealing a compelling splice donor variant in signaling lymphocytic activation molecule 1 (SLAMF1), a transmembrane receptor with important functions in immune cells. The SLAMF1 discovery and study approach will be discussed, along with insights into more recent analyses at Wisdom.