Hypertrophic cardiomyopathy (HCM) is a common heritable myocardial disease in cats. In humans, HCM is typically caused by mutations in cardiac sarcomere protein genes and occasionally in non-sarcomeric genes. In cats only 2 causative mutations for HCM have been identified so far; both in the sarcomeric gene MYBPC3. We hypothesised that HCM in cats is Read more about Candidate genes for feline hypertrophic cardiomyopathy: analysis of 18 sarcomeric and non-sarcomeric genes[…]

Diabetes mellitus (DM) in cats resembles type 2 DM in humans. A genome-wide association study of DM in Domestic Shorthair (DSH) cats identified 3 single nucleotide polymorphisms (SNPs) located at the end of chromosome A3. The ACP1 gene, coding for a protein tyrosine phosphatase involved in insulin signalling, is in close proximity to these SNPs Read more about Single nucleotide polymorphisms in the feline ACP1 gene are associated with diabetes mellitus in lean Domestic Shorthair cats[…]