Dilated cardiomyopathy (DCM) is a breed-specific, high prevalence disorder in Doberman Pinschers. However, the genetic background of DCM and its relationship to cardiac arrhythmias remains largely unknown. To uncover the genetic risk loci and variants that are associated with DCM, we have established a cohort of over 550 Dobermans with cardiological examination, which included echography, Read more about A novel locus in chromosome 5 is associated with dilated cardiomyopathy in Doberman Pinschers[…]

Recent efforts have extended the dog genome annotation with the discovery of thousands of long non coding RNAs (lncRNAs) using the machine-learning based tool FEELnc [1]. Although lncRNAs have been shown to play important roles in many biological processes, and particularly in cancers [2], it remains challenging to assign functions and classify lncRNAs in order Read more about Integrated genomic and transcriptomic analyses of long non-coding RNAs in dog as a model of human melanoma[…]

Canine atopic dermatitis (cAD) is a common clinical syndrome with no definitive diagnostic tests, which causes marked morbidity and has a high economic impact. Past efforts at evaluating the epidemiology and genetics of cAD have relied upon extensive clinical examination to identify subjects, which has limited sample sizes. In this study, we created a novel Read more about Genetic and environmental risk factors for canine atopic dermatitis evaluated in a population of owned Labrador and Golden retrievers[…]