Data cleaning; is it time to stop sweeping it under the carpet? An example from the Dogslife project.

Even with careful study design and extensive validation, large datasets are often heterogeneous and require cleaning prior to analysis to prevent losses in research validity, quality and statistical power. Many publications report that data was ‘cleaned’ but few studies document the process reproducibly and values identified as ‘outliers’ are commonly deleted without reporting the possible Read more about Data cleaning; is it time to stop sweeping it under the carpet? An example from the Dogslife project.[…]

Detection and Characterisation of a Genetic Association with Norwich Terrier Upper Airway Syndrome

In domestic dogs, the “flat-faced” brachycephalic head shape is a risk factor for developing the respiratory defect, Brachycephalic Obstructive Airway Syndrome (BOAS). As the popularity of breeds such as the French bulldog continues to increase in the UK, so too are the expected incidences of BOAS. For this reason, we became interested in the Norwich Read more about Detection and Characterisation of a Genetic Association with Norwich Terrier Upper Airway Syndrome[…]

Association of primary open angle glaucoma ADAMTS17 mutations with height in two domestic dog breeds

There are currently five known ADAMTS17 mutations in the dog that are associated with the development of either primary open angle glaucoma or primary lens luxation. Interestingly, these mutations have been identified in breeds of generally short stature including terriers and Basset breeds. In humans, mutations in the ADAMTS17 gene are associated with Weill-Marchesani syndrome Read more about Association of primary open angle glaucoma ADAMTS17 mutations with height in two domestic dog breeds[…]

Swedish actions to “handle” Brachycephalic Obstructive Airway Syndrome (BOAS) related health issues

The poster is reviewing Swedish actions to improve health issues related to Brachycephalic Obstructive Airway Syndrome (BOAS) and handling the increased attention and awareness of the syndrome. These actions are forming of working groups composed of various stakeholders, arranging conferences and production of educational material for breeders, judges and veterinarians (a,b). reviewing the epidemiology of Read more about Swedish actions to “handle” Brachycephalic Obstructive Airway Syndrome (BOAS) related health issues[…]