Population structure of Leonberger dogs

The Leonberger is a giant dog breed formed in the 1850s in Germany. This breed appears to have higher predisposition to neurodegenerative disorders and osteosarcoma than other breeds. Every second polyneuropathy-diagnosed Leonberger can be explained by dominantly inherited ARHGEF10 or GJA9 variants and a recently described recessive NAPEPLD variant identifies a juvenile-onset leukoencephalomyelopathy. Breeders also Read more about Population structure of Leonberger dogs[…]