Dog represents a spontaneous model of many genetic diseases including cancers and other multifactorial diseases as well as monogenic diseases. The last 10 years, genetic tools dedicated to dogs allowed to identify the genetic causes or predisposition to canine and human homologous genetic conditions. More recently, the idea emerged that dogs can be of help Read more about Cani-DNA: a French National biobank of canine samples for dog/human compared biomedical research.[…]

The advent of whole genome sequencing (WGS) has promised to revolutionise genetic research, and the rapid fall in per-sample costs in recent years has made the revolution an affordable reality for geneticists. The technology is especially useful for the study of simple Mendelian conditions where disease-causing mutations have the potential to be identified from the Read more about Give a Dog a Genome: generating a stake-holder funded bank of whole-genome sequences with which to elucidate benign and disease-associated variation within the canine genome[…]

Genetic improvement with the use of Estimated Breeding Values (EBV) is a method which, after decades of successful and validated use in livestock species, slowly gains recognition in the world of dogs breeding. However, accurate EBV prediction for complex traits requires large datasets of phenotyped and related animals. While generation of such datasets is possible Read more about Use of cross-country data for estimation of heritability of longevity and heart-related deaths in Doberman Pinscher[…]

In humans, there are many forms of sensory neuropathies, associated or not with a loss of sensitivity to pain and sometimes accompanied by self-mutilation. Although to date 13 genes have already been implicated in this disease, they do not explain the genetic causes of all patients. Similar neuropathies are diagnosed in dogs and several breeds Read more about A dog spontaneous model for human sensory neuropathies: Identification of a mutation in a regulatory region of GDNF and DNA screening in human patients.[…]

Dilated cardiomyopathy (DCM) is a breed-specific, high prevalence disorder in Doberman Pinschers. However, the genetic background of DCM and its relationship to cardiac arrhythmias remains largely unknown. To uncover the genetic risk loci and variants that are associated with DCM, we have established a cohort of over 550 Dobermans with cardiological examination, which included echography, Read more about A novel locus in chromosome 5 is associated with dilated cardiomyopathy in Doberman Pinschers[…]

Recent efforts have extended the dog genome annotation with the discovery of thousands of long non coding RNAs (lncRNAs) using the machine-learning based tool FEELnc [1]. Although lncRNAs have been shown to play important roles in many biological processes, and particularly in cancers [2], it remains challenging to assign functions and classify lncRNAs in order Read more about Integrated genomic and transcriptomic analyses of long non-coding RNAs in dog as a model of human melanoma[…]

Canine atopic dermatitis (cAD) is a common clinical syndrome with no definitive diagnostic tests, which causes marked morbidity and has a high economic impact. Past efforts at evaluating the epidemiology and genetics of cAD have relied upon extensive clinical examination to identify subjects, which has limited sample sizes. In this study, we created a novel Read more about Genetic and environmental risk factors for canine atopic dermatitis evaluated in a population of owned Labrador and Golden retrievers[…]